3C process

3C Continuous Counter Current bioprocessing technology

BioSanaPharma_3C Process lab_final_Aug 0

The 3C technology platform is a high productivity, flexible, small footprint (50m2) manufacturing platform capable of making 1kg of drug substance antibody per week at a 50L bioreactor scale. Batch processing is made continuous with multicycle counter current operation. The upstream process is based on High Cell Density continuous perfusion culturing with alternating bioreactor use (our IP) and the down stream process is based on Simulated Moving Bed chromatography combined with flow through filtration. The process has GMP status and is designed to run for up to 2 months. All steps run in parallel while interconnected via smart software (21 CFR part II) for flow control and data acquisition (currently being implemented).